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Novel drug delivery method: a protein "cage"

Dr. Jorg Stetefeld has developed a novel way to deliver small molecule drugs within a protein “cage”. This may be used to: · Deliver relatively insoluble drugs. · It may be used to alter drug release, absorption, distribution, metabolism and elimination. · The technology also provides a method to produce bio-engineered...

Published: 3/16/2010 | Updated: 3/16/2010 | Inventor(s): Jorg Stetefeld

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Category(s): Physical Sciences

Improved diagnostic test for estrogen receptor status in breast cancer - multiple phosphorylation state

Estrogen receptor (Erα) status has become widely used as a key predictive biomarker of potential responsiveness to endocrine therapy in breast cancer. Positive receptor status predicts a positive outcome to endocrine therapy. This includes both estrogen analogue (including Tamoxifen) therapy and aromatase inhibitor therapy. It was subsequently...

Published: 3/15/2010 | Updated: 3/15/2010 | Inventor(s): Gilbert Arthur, Robert Bittman

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Category(s): Physical Sciences

Novel antibiotic chemistries: aminoglycoside-based cationic amphiphiles

The antibiotics markets: The total world market is in the range of $25 billion a year and it is growing, at a time when the antibiotics pipeline is “bone dry”. The Schwiezer/Zhanel technology offers an important new opportunity with the aminoglycoside molecules; a class well established for its effectiveness and well understood safety profile. Aminoglycosides...

Published: 3/15/2010 | Updated: 3/15/2010 | Inventor(s): Frank Schweizer

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Category(s): Physical Sciences

A practical conducting polymer High molecular weight, self-doped Poly(anilineboronic acid)

The promise of the electrically-conducting polymers has been hampered until now The electrically conducting polymers are of great potential applicability in industrial manufacture and use, however they have been hampered by low yields, low molecular weight polymers resulting in poor mechanical strength and stability. Also the materials are difficult...

Published: 3/15/2010 | Updated: 1/22/2010 | Inventor(s): Michael Freund, Bhavana Deore, Insun Yu

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Category(s): Physical Sciences